As essential genes in the strigolactone pathway, the divergence timing of the conserved CCD7 and CCD8 genes reflects the approximate time of generation of strigolactone as a regulatory substance. This timing calculation also coincides with initiation of symbiosis between plants and microorganisms, inferred from the fossil record. Molecular evolution analyses of genes in metabolic pathways can provide insight concerning gene evolution.”
“Vascular endothelial growth factor (VEGF) is an endothelial cell-specific mitogen involved PCI-34051 in a number of pathologic processes,
including angiogenesis, tumor growth and metastasis. Polymorphisms of the VEGF gene have been associated with susceptibility to colorectal cancer (CRC). However, the specific association still remains controversial. We made a meta-analysis of the association between VEGF gene polymorphisms and CRC risk. Only eight case-control studies were retrieved, with a total of 2337 CRC patients and 2032 healthy controls. Six VEGF gene polymorphisms were addressed in all studies included, + 936C>T (rs3025039), -2578C>A (rs699947), -1154G>A (rs1570360), -634G>C (rs2010963), -460C>T (rs833061), and +405C>G (rs2010963). There Pexidartinib research buy was
a significant association between -2578C>A polymorphism and susceptibility to CRC in the comparison of C allele carriers (CC + CA) versus AA (odds ratio = 0.77, 95% confidence interval = 0.62-0.96, P = 0.02). No association was found between + 936C>T, -1154G>A, -634G>C, -460C>T, and +405C>G with susceptibility to CRC. We conclude that the C allele carrier (CC + CA) of VEGF -2578C>A polymorphism appears to be a protective factor for CRC.”
“The assessment of experimental and theoretical results SB273005 shows controversy about the mechanical stability of OsC phases. The stability of WC-structured, NiAs-structured, and CoSn-structured OsC phases has been investigated by using first-principles calculations. Present results show that WC-OsC and NiAs-OsC are both unstable, energetically and vibrationally, at zero pressure. Further calculations show WC-OsC can be stabilized under high pressure but not NiAs-OsC, which is unstable even under very high pressure.
It is found that the interaction between Os atoms in parallel x-y plane is responsible for the deep instability of NiAs structure, while the greatly increased interaction under high pressure between nearest C-Os atoms is responsible for the stabilization of WC-OsC under high pressure. (C) 2010 American Institute of Physics. [doi:10.1063/1.3500325]“
“To gain insight into stress-responsive gene regulation in soybean plants, we identified consensus sequences that could categorize the transcription factors MYBJ7, BZIP50, C2H2, and NAC2 as members of the gene families myb, bzip, c2h2, and nac, respectively. We also investigated the evolutionary relationship of these transcription factors and analyzed their expression levels under drought stress.