7%), while posterior compartment prolapse (rectocele) stage a parts per thousand yenaEuro parts per thousand 2 was present in three (5.7%). Voiding symptoms were resolved in 42 out of
45 patients (93.4%) and storage symptoms in 30 out of 36 (83.3%); one patient reported de novo urgency. Sexual activity was maintained in 28 out of 29 patients (95.5%). Four patients showed de novo stress urinary incontinence.
Our findings support the use of uterus preservation, with significative objective and subjective outcomes in treating POP.”
“Study Design. Systematic review.
Objective. To evaluate the current biomechanical and clinical evidence available on the use and effectiveness INCB024360 chemical structure of lumbar interspinous devices and to recommend indications for their use.
Summary of Background Data. Lumbar interspinous spacers (ISPs) have recently become popular as an alternative treatment for lumbar degenerative disease. Several spacers are currently available in the market and there have been various proposed indications. The relevant biomechanical and clinical papers are analyzed.
Methods. A systematic review of clinical and biomechanical
studies was done using the following key words: interspinous implants, interspinous devices, interspinous spacers, dynamic stabilization, X-STOP, Coflex, Wallis, DIAM. The database inclusions were MEDLINE, CINAHL (Cumulative Index to Nursing and Allied Health Literature), selleck chemical and PubMed. The main outcome measure Selleckchem GW4869 was clinical outcome assessment based on validated patient-related questionnaires. Biomechanical
studies were analyzed to evaluate the effects of ISPs on the kinematics of the spine. The methodology of the clinical studies was also analyzed.
Results. Largest number of studies has been with the X-STOP device. The biomechanical studies with all the devices showed that ISPs have a beneficial effect on the kinematics of the degenerative spine. Apart from 2 randomized controlled trials, the other studies with the X-STOP device were not of high methodologic quality. Nevertheless, analysis of these studies showed that X-STOP may improve outcome when compared to nonoperative treatment in select group of patients aged 50 or over, with radiologically confirmed lumbar canal stenosis and neurogenic claudication, who have improvement of their symptoms in flexion. Studies on the other devices show satisfactory outcome to varying degrees. However, due to small number and poor design of the studies, it is difficult to clearly define indications for their use in lumbar degenerative disease.
Conclusion. Lumbar ISPs may have a potential beneficial effect in select group of patients with degenerative disease of the lumbar spine. However, further good quality trials are needed to clearly outline the indications for their use.