As the present study examined schizotypy at the non-clinical level, it is likely that symptoms at this stage are not severe enough to produce dysfunctional

left hemisphere activity. However, previous studies that have also explored language processing at the non-clinical level of schizotypy have yielded mixed results. Many of which, contrary to the present study, have demonstrated atypical language lateralisation in high Protein Tyrosine Kinase inhibitor schizotypal participants, similar to, but less severe than those observed in schizophrenia (Broks et al., 1984, Overby, 1992 and Rawlings et al., 1987). Thus, differences in the level of symptoms may not be sufficient in explaining the differences in lateralisation patterns. A more sophisticated explanation for

the discrepancies in findings may be attributable to the specific types of symptoms experienced across the samples. Green and colleagues (1994) argued that in schizophrenia, hallucinations, as opposed to psychotic symptoms in general, are the specific trait that produce impaired performance on dichotic listening measures. The authors propose that this is a result of the left hemisphere attending to inner speech and voices BMS-354825 cell line during auditory hallucinations. Further evidence of the significant role that positive symptoms such as hallucinations play in producing atypical laterality was demonstrated by Conn and Posey (2000), who used the dichotic listening paradigm to compare the performance of healthy college students who report verbal hallucinations with college students who report no previous history of this. The authors confirmed that only participants who had reported experiencing auditory hallucinations demonstrated impaired performance, specifically for the detection of words, and thus indicative of left hemisphere dysfunction. The present study tested healthy individuals at the non-clinical level of the schizotypy spectrum who were unlikely to experience hallucinatory symptoms and thus did not demonstrate abnormal lateralisation. In Avelestat (AZD9668) contrast to the collection of research examining language laterality,

this was the first known study to explore hemispheric responses to emotional prosody in non-clinical schizotypy. In line with previous emotion recognition research within this population (Aguirre et al., 2008; Phillips & Seidman, 2008), reduced sensitivity for the detection of emotional prosody was observed within the high schizotypal personality group. As most examinations of emotion perception abilities in schizotypy and schizophrenia tend to focus predominantly on facial affect (Toomey & Schuldberg, 1995), this highlights the importance of investigating prosody, as it appears that impaired emotion recognition is not limited solely to facial affect. Most importantly, however, was the finding of typical right hemisphere specialisation for the detection of emotional tones across the sensitivity and reaction time data.