Conclusions: This study provides accurate
estimates of the economic costs and relative cost-effectiveness of three different strategies for training community program clinicians in motivational interviewing and should be of interest to decision makers seeking to implement empirically supported addiction treatments with scarce resources. (C) 2011 Elsevier Ireland Ltd. All rights reserved.”
“In order to extend our knowledge concerning karyotypes of the genus Vernonia, we applied various techniques of chromosome banding, including AgNOR and triple staining with the fluorochromes CMA/DA/DAPI (CDD), and of fluorescent in situ hybridization (FISH) for the 45S rDNA probe to specimens of two populations of Vernonia geminata collected from an open-pasture area, in southern Brazil. B chromosomes were observed in one of the OSI906 populations. Both populations of V. geminata presented a Nepicastat inhibitor pair of CMA(3)(+) terminal bands and one pair of chromosomes with terminal AgNOR banding. The FISH evidenced, in one population, two pairs of small sites of 45S rDNA; these being two small terminal sites and two centromeric sites. In
the other population, there was only one pair of small terminal sites and two sites in two B chromosomes, one in each chromosome. There was coincidence of localization between CMA(+) and NOR bands with one of the small terminal sites of 45S rDNA of one chromosome of the normal complement, but not in B chromosomes.”
“Background: Methamphetamine’s behavioral effects have been attributed
to its interaction with monoamine transporters; however, methamphetamine also has affinity for sigma receptors.
Method: The present study investigated the effect of the sigma receptor agonist SB525334 mw SA 4503 and the sigma receptor antagonists BD-1047 and BD-1063 on methamphetamine-evoked [H-3]dopamine release from preloaded rat striatal slices. The effect of SA 4503 on methamphetamine-induced hyperactivity and on the discriminative stimulus properties of methamphetamine also was determined.
Results: SA 4503 attenuated methamphetamine-evoked [H-3]dopamine release in a concentration-dependent manner. BD-1047 and BD-1063 did not affect release. SA 4503 dose-dependently potentiated and attenuated methamphetamine-induced hyperactivity. SA 4503 pretreatment augmented the stimulus properties of methamphetamine.
Conclusions: Our findings indicate that SA 4503 both enhances and inhibits methamphetamine’s effects and that sigma receptors are involved in the neurochemical, locomotor stimulatory and discriminative stimulus properties of methamphetamine. (C) 2011 Elsevier Ireland Ltd. All rights reserved.”
“We sequenced the complete mitochondrial genome of Phalera flavescens.