In this study we evaluated whether the effects of total
HLA, Class I and Class II MM were more important determinants of: (1) recipient survival; (2) development of bronchiolitis obliterans (BO); and (3) freedom from acute rejection PFTα manufacturer (AR).
METHODS: All adult primary cadaveric lung recipients transplanted between April 1, 1994, and June 30, 2004 entered in the OPTN database were included (n = 9,791). Groups were created based on the total number of HLA, Class I and Class II MM. Recipient survival, freedom from AR and freedom from BO were compared. Univariate data were computed using the Kaplan-Meier method and compared by log-rank test. Multivariate analysis was performed using the Cox proportional hazards method.
RESULTS: Univariate analysis identified significantly improved survival
in recipients with fewer total HLA (p <0.001) and Class I MM (p = 0.005). The incidence of BO was significantly lower in patients with fewer total Class I MM (p = 0.036). AR was influenced only by Class II MM (p = 0.005). By multivariate analysis, total HLA, Class I and Class II MM impacted recipient survival. Total HLA and Class I MM correlated with development of BO. Class II MM correlated with development of AR.
CONCLUSION: HLA MM are important determinants of lung transplant survival, BO and AR. These data suggest that donor-recipient selleck chemicals llc HLA MM may warrant consideration when allocating organs for lung transplantation. selleck chemicals J Heart Lung Transplant 2011;30:426-34 (C) 2011 International Society for Heart and Lung Transplantation. All rights reserved.”
“With the help of the nonequilibrium Green’s function method, we have investigated the
Josephson current properties of a triple quantum dot molecule. It is found that the sign of the Josephson current can be changed from positive to negative with increasing the spin-flip scattering, which leads to the pi-junction transition. By tuning the system parameters, such as the gate voltage, the interdot coupling, and spin-flip strength, it is manifested that the pi-junction not only can be controlled, but also the oscillation of the Josephson current versus magnetic flux can be changed. The pi-junction is explained in terms of the picture of the current carrying density of states. These results provide the ways of manipulating the Josephson current. (C) 2010 American Institute of Physics. [doi: 10.1063/1.3525996]“
“BACKGROUND: The incidence of endothelitis in cardiac transplants, and the relationship to clinical symptoms and humoral rejection, is unclear. Recently, the finding of intravascular macrophages has been found to represent antibody-mediated rejection. This study investigated the role of intravascular T lymphocytes in antibody-mediated rejection.
METHODS: A total of 819 sequential biopsy specimens from 93 cardiac allograft recipients were prospectively studied.