Over the years, vaccine development has generally followed progress in areas like protein chemistry and molecular biology, with the more recent emergence of effective products based on recombinant DNA (hepatitis B) and virus-like particle (human papillomavirus) technology being cases in point. That process continues, but what has emerged recently is a new fascination with the way that the early, innate response INNO-406 sets up the specific,

adaptive immunity and memory that is the basis of vaccination. The application of systems biology and the discovery of ‘molecular machines’, like the inflammasome, that influence immunogenicity, are translating into the development of a whole new spectrum of adjuvants, and organisms engineered to enhance long-term protection. Given the recent (October 2010) educational experience of being required to listen closely so that I could present an hour-long summing up of a joint, 4-day

Keystone/Gates Foundation symposium on vaccination, I became acutely aware of a new optimism among the vaccinologists, as they test novel products and show better levels of responsiveness in those most difficult target populations, the very young, the elderly and children who suffer from poor nutrition and intercurrent infections as an accident of their birth in the poorer Compound Library nations of this small planet. In addition, we are also developing a better understanding of how to limit the possibility of untoward side effects (reactogenicity) that have led some parents in the wealthy, western societies to reject childhood vaccination, at times with fatal consequences. This new book conveys some of the excitement of what is happening in vaccine research and development. It is aimed at healthcare professionals, students and other professionals involved in public health and disease prevention who are not experts in vaccinology and would like to know more. The rise of the internet, which provides

equivalent access to good and bad information, highlights that nothing can be taken for granted when it comes to the interface between science and society. Scientists must reach out to explain what they are doing and how it is that their efforts benefit humanity. As such, the present book is a useful, well-motivated and comprehensive contribution SSR128129E on a topic that should be of vital interest to every responsible health educator, parent and citizen. “
“Miss Jennings, a nurse, died at the Glendale hospital Thursday evening at 6 o’clock. Miss Jennings took sick with influenza several days ago and grew worse until the end came last evening. She was 22 years of age and was in her second year of training. This is the third nurse that has died at the hospital this week of influenza. They paid the supreme sacrifice while caring for the sick of the community. Each girl worked as long as she could be on her feet, regardless of her own feelings.