Patients were grouped based on the presence/absence of appropriate ICD therapy. Summary data and stored electrograms from ICDs were reviewed to determine appropriateness of therapy. Predictors of therapy were assessed by both univariate and multivariate Cox regression analysis.

Results:

Of 421 primary prevention patients undergoing ICD implantation, 79 (19%) had received appropriate ICD therapies. By univariate comparison, nonsustained ventricular tachycardia (NSVT), male sex, left ventricle diastolic diameter (LVDD), and hypertension were all significant predictors for ICD therapy over a mean follow-up time of 751 +/- 493 days (P <= 0.05). The use of beta-blockers was found to be a negative predictor. In the ischemic cardiomyopathy (ICM) population, 55 (17%) patients received ICD therapy and this was predicted by 7-Cl-O-Nec1 chemical structure NSVT, hypertension, LVDD, and left atrial diameter. beta-blockers were protective. In the nonischemic dilated cardiomyopathy (NIDCM) population, 24 (23%) received appropriate therapies, which were predicted by NSVT, male sex, dual chamber device, lack of biventricular device, and lack of beta-blockers. By multivariate analysis, NSVT, hypertension,

and lack of beta-blockers were significant for ICM, while NSVT and absence of beta-blockers were predictive for NIDCM. Ejection fraction, New York Heart Association class, and QRS width were not significantly different between therapy and no-therapy selleck groups in any population.

Conclusions: ICD-delivered therapy occurred in 19% of primary prevention patients with both ischemic and dilated cardiomyopathy and was predicted by NSVT and a lack of beta-blocker use. (PACE 2010; 33:320-329)”
“Objective-To SC79 order investigate cardiovascular changes and survival times following complete interventional device occlusion of uncomplicated left-to-right shunting patent ductus arteriosus in dogs.

Design-Retrospective cohort study.

Animals-24 dogs with uncomplicated patent ductus

arteriosus that was fully occluded and reevaluated within 24 hours, approximately 3 months, and 1 year after the procedure.

Procedures-Information on medical history, diagnostic imaging findings, treatment received, and survival times were obtained from medical records. Patients were allocated into 2 groups on the basis of age (< 1 year En = 141 and >= 1 year HOD at the time of the procedure. Additional follow-up information was obtained through interviews of owners and referral veterinarians.

Results-Following ductal occlusion, decreases were detected in vertebral heart scale size, left ventricular chamber diameter in diastole and in systole, left atrial dimension, fractional shortening, aortic velocity, and ventricular wall thickness. There were no differences between age groups for postocclusion changes except vertebral heart scale size. Systolic dysfunction was detected in 14 (58%) patients on the final visit.