Taken together, these findings are consistent with the view that MDD is marked by a decline in RM, which is underpinned by an impairment in recollection rather than familiarity processes. The extent to which the recollection deficiencies arise from disruption of strategic memory and executive processes requires further investigation. (C) 2008 Elsevier Ireland Ltd. All rights reserved.”
“L-3,4-Dihydroxyphenylalanine (L-DOPA), the gold standard therapy for Parkinson disease (PD), is associated with motor fluctuations
selleck compound and dyskinesias. This study sought to prevent the development of L-DOPA-induced dyskinesias (LID) with the metabotropic glutamate receptor type 5 (mGlu5 receptor) antagonist 2-methyl-6-(phenylethynyl)pyridine (MPEP) Selleck URMC-099 in the de nova treatment of monkeys lesioned with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) as a PD model. MPTP-lesioned
monkeys were treated once daily for one month with either L-DOPA or L-DOPA + MPEP (10 mg/kg). MPEP (administered 15 min before L-DOPA) plasma concentrations were elevated during all the L-DOPA motor activation and did not accumulate during a month. The antiparkinsonian effect was maintained throughout the treatment period in MPTP-lesioned monkeys treated with L-DOPA + MPEP, while the duration of this effect decreased over time in MPTP-lesioned monkeys treated with L-DOPA alone, suggesting wearing-off. Over the month-long treatment, click here the mean dyskinesia score increased in L-DOPA-treated monkeys; interestingly, this increase was reduced by overall MPTP-lesioned in the L-DOPA
+ MPEP group. Mean dyskinesia scores of monkeys correlated inversely with plasma MPEP concentrations. Normal control and saline-treated MPTP-lesioned monkeys were also included for biochemical analyses. All MPTP-lesioned monkeys were extensively and similarly denervated. [H-3]ABP688 specific binding to mGlu5 receptors increased in the putamen of L-DOPA-treated monkeys compared to control, saline or L-DOPA + MPEP-treated monkeys. Mean dyskinesia scores of MPTP-lesioned monkeys correlated positively with [H-3]ABP688 specific binding in the putamen. This study showed a beneficial chronic antidyskinetic effect of MPEP in de novo L-DOPA-treated MPTP-lesioned monkeys, supporting the therapeutic use of mGlu5 receptor antagonists in PD to prevent LID.
This article is part of a Special Issue entitled ‘Metabotropic Glutamate Receptors’. (c) 2012 Elsevier Ltd. All rights reserved.”
“Police work is one of the most stressful occupations. Previous research has indicated that work stress and trauma exposure may place individuals at heightened risk for the development of depression symptomatology. This prospective longitudinal study was designed to examine predictors of depression symptoms in police service. Participants comprised 119 healthy police recruits from an ongoing prospective study.