We note that the tablets contain a high amount of polymer (30 wt%) and that preliminary experiments have shown that by decreasing the amount of polymer the extended release time can be decreased (unpublished

data). The release is strongly affected by the presence of surfactant and/or buffer, which affects both the solubility of CLHMPAA and the maximum swelling of the gel layer that surrounds the disintegrating tablets. Importantly, two mechanisms of tablet disintegration were observed under shear, that is, conventional dissolution of a soluble tablet matrix or erosion selleck of swollen insoluble gel particles from the tablet. Interestingly, the effects from surfactant in the surrounding medium can be circumvented by addition of surfactant to the tablet. With added surfactant, tablets that might not be susceptible to Inhibitor Library cost the differences in bile salt level between fasted or fed states have been produced. This should be further evaluated using simulated intestinal

fluid, e.g. FaSSIF/FeSSIF, which could also include optimisation of the extended dissolution time. This suggests that the potential of CLHMPAA and surfactant in tablet formulations is high and that further studies should be conducted. This includes optimising the content of Pemulen to give a desired time frame of release as well as obtaining approval for oral use of the polymer. “
“Generic drugs contain the same active ingredients as brand-name drugs and are less expensive buy Cobimetinib than their brand-name counterparts, but they are considered to have equivalent quality. Since generics and their brand-name counterparts have different additives such as preservatives and coloring agents, the quality of generics is often questioned by physicians and pharmacists [1]. Studies have questioned the equivalence of some generics to their brand-name counterparts in terms of clinical efficacy and safety, and there is a lack of clinical information and data on the clinical efficacy and

safety of generics [2,3]. Drugs applied to the skin consist of transdermal preparations, in which drugs act by traveling throughout the body, and topical preparations, in which drugs are applied externally to a certain place on the skin. The latter are most often semisolid preparations in the form of ointments, creams, and gels, liquids such as lotions, and adhesive preparations such as cataplasms/gel patches and tapes. Bases differ vastly among brand-name topical preparations and their generic counterparts, and the characteristics of these bases may differ. Ointments are drugs largely consisting of additives such as thickening agents and pH adjusters. Clinical efficacy, adverse reactions, and feel may differ due to factors such as bases and additives and the site of use despite drugs having the same principal agent [4].