With recent clinical trials reporting negative outcomes with rEpo in the treatment of cancer-related anemia, with increased mortality in those who received rEpo, it has become necessary for nephrologists
to analyze and review the effect of use of rEpo in treatment of anemia of CKD in patients who may have current or previously treated malignancy. It is known that CKD patients have an increased prevalence of certain malignancies (Wong G et al. Association of CKD and cancer risk in older people. J Am Soc Nephrol. 2009;20(6):1341-1350). If a CKD patient develops see more cancer or has a previous history of cancer, there is a dilemma which faces the treating nephrologist with respect to the use of rEpo in this situation. So far this issue has been addressed infrequently in the nephrology literature, selleck chemicals and the guidelines are unclear. This review describes Epo and EpoR biology, reviews Use of rEpo for treatment of cancer-related anemia and makes a case to the nephrology community for the careful use of rEpo in CKD patients with cancer.”
“Heat assisted magnetic recording (HAMR) is one of the leading technologies to extend magnetic
storage. Significant progress has been achieved in head and media fabrication [M. Seigler et al., IEEE Trans. Magn. 44, 119 (2008); Y. Peng et al., TMRC, Seagate Research, 2008], resulting in a basic technology demonstration (C. Hardie et al., ODS Conference Proceedings, 2008) of HAMR. Both field and
field-gradient limitations of a conventional perpendicular recording are overcome by engineering the thermal profile (notably the gradient) and recording at a temperature near T(c) (thus requiring a smaller head field). We have used a micromagnetic recording model to study the effect of thermal and field-gradient alignment in HAMR by varying the separation between the thermal spot and the leading edge of the head field. The output of the recording model includes transition Selleck EX527 jitter, which is based on Monte Carlo simulations of isolated transitions. We use a realistic granular medium with H(K)similar to 50-80 kOe and a grain size of similar to 2.5-6 nm that covers a broad range of HAMR media parameters. The model indicates that HAMR can achieve >1 Tbyte/in.(2) using a grain size of 6 nm and is scalable to >4 Tbyte/in.(2) on a granular media by careful alignment of the thermal and magnetic field gradients. (C) 2009 American Institute of Physics. [DOI: 10.1063/1.3073948]“
“This study investigated the outcome of a 5-day headache-specific multidisciplinary treatment program (MTP) and the adherence to treatment recommendations in 295 prospectively recruited consecutive headache patients [210 migraine, 17 tension-type headache (TTH), 68 combination headache, including 56 medication-overuse headache (MOH)]. Headache frequency decreased from 13.4 (+/- 8.8) to 8.8 (+/- 8.0) days per month after 12-18 months.