ZLJ-6 significantly reduced thrombus formation in ferric chloride-induced rat arterial thrombosis and plasma TXB(2), 6-keto-PGF(1 alpha) and LTB4 levels in vivo. In vitro, arachidonic acid (AA) and collagen-induced platelet aggregation was inhibited by ZLJ-6 in a concentration-dependent manner. The see more inhibitory effect of ZLJ-6 on the conversion from AA to TXB(2) and PGD(2) in vitro further confirmed its COX-1 mediated antiplatelet mechanism. On the contrary,
coagulation parameters were not altered by ZLJ-6. These results obtained in this study identify ZLJ-6 as a promising antithrombotic agent with potential clinical application in the modulation of thrombotic disorders.”
“Zidovudine is a drug used for the treatment of AIDS. The objective of this work was to prepare tablets for modified release of zidovudine. Hydroxypropyl methylcellulose HPMC K100LV and HPMC K4M at 1250 %, 18.75 % and 25.00 % were used. The tablets produced with 12.50 % of HPMC reached 100 % of the zidovudine release in 6 hours, while
those produced with 18.75 and 25.00 %, released 24 h, following the Higuchi and First Order kinetic models, respectively. The calculated release exponent AZD6244 in vivo pointed out that formulations follow the anomalous type of release mechanism, with a combined phenomena of diffusion and erosion.”
“Animal models are key elements of surgical research and promotion of new techniques. Inanimate models, anatomical specimens, and living animals are all necessary to solve the various problems encountered by the advent of a new surgical technique. The development of Natural Orifice Transluminal Endoscopic Surgery (NOTES) procedures is a representative model.
Over 400 experimental procedures were performed in inanimate models, ex vivo tissues and animals to solve all problems faced by the development of NOTES surgery: peritoneal access, gastrotomy closure, exposure, retraction, dissection as well as education to start this new procedure.
The successive use of all models allows to identify the ideal solution for each problem and to precisely define the safest and most reliable option to apply the new technique in patients.
It allowed to perform the first transvaginal GSK1904529A and transgastric cholecystectomy in patients in a safe way.
Animal experimentation remains necessary as even sophisticated computer-based solutions are unable to model all interactions between molecules, cells, tissues, organisms, and their environment. Animal research is required in many areas to validate new technologies, develop training, let alone its major goal (namely to avoid using patients for experimentation) which is to be the first “”model”" for the surgeon.”
“The aim of the study was to characterize the preclinical pharmacokinetics and comparative pharmacokinetics of pure vitexin-2 ”-O-rhamnoside (VR) in mice after oral and intravenous administration at dose of 30 mg/kg.