However, a negative correlation was found between recognition based on familiarity and levels of intoxication.
Alcohol-induced impairments in recognition memory occur in a dose-dependent manner, specifically driven by reductions in recognition associated with conscious awareness.”
“Theorems offer a rarity in biology, a guarantee that something will always be true if certain conditions are met. We show that modeling and theorem proving are distinct while playing mutually supporting roles in understanding cellular phenomena. Using two recently proven theorems from systems biology
as examples, we demonstrate that theorems are not an alternative to mechanistic models. Rather, theorem proving, in conjunction with conventional mathematical (mechanistic) modeling, is an essential tool for a deeper understanding in systems biology. (C) 2011 Elsevier Ltd. All rights reserved.”
“Neuronal 17DMAG histamine has a prominent role in sleep-wake control and body homeostasis, but a number of studies suggest that histamine has also a role in higher brain functions including drug reward.
The present experiments characterized the involvement of histamine and its H3 receptor in ethanol-related behaviors in mice.
Male histidine decarboxylase knockout (HDC KO)
and control mice were used to study the role of histamine in ethanol-induced stimulation of locomotor activity, Selumetinib impairment of motor coordination, and conditioned place preference (CPP). Male C57BL/6Sca mice were used to study the effects of H3 receptor antagonist in the effects of ethanol on locomotor activity.
The HDC KO mice displayed a weaker stimulatory response to acute ethanol than the wild-type (WT) mice. No differences between genotypes were found after ethanol administration on accelerating rotarod. The HDC KO mice showed stronger ethanol-induced CPP than the WT mice.
Binding of the GABA(A) receptor ligand [(3)H]Ro15-4513 was not markedly changed in HDC KO mouse IMP dehydrogenase brain and thus could not explain altered responses in KO mice. Ethanol increased the activity of C57BL/6Sca mice, and H3 receptor antagonist ciproxifan inhibited this stimulation. In CPP paradigm ciproxifan, an H3 receptor inverse agonist potentiated ethanol reward.
Histaminergic neurotransmission seems to be necessary for the stimulatory effect of ethanol to occur, whereas lack of histamine leads to changes that enhance the conditioned reward by ethanol. Our findings also suggest a role for histamine H3 receptor in modulation of the ethanol stimulation and reward.”
“Although major depressive disorder (MDD) is a serious neuropsychiatric illness, it’s pathogenesis remains unclear. Current evidence suggests that the abnormal transmission and plasticity of hippocampal synapses play an important role in the pathogenesis of MDD.