’ In terms of endocrine problems, the Atlas reported on diabetes-related amputations,

the percentage of people recorded as receiving nine key diabetes care processes, and rates of bariatic surgery.1 For amputation the results show a variation from around 1.5 per 1000 patients with type 2 diabetes undergoing lower extremity amputation in South East England and the West Midlands to 3 per 1000 patients in South West England. The percentage of patients receiving nine key care processes in diabetes varied from 2% to 70% across all primary care trusts in England. What factors may contribute to a two-fold variation in amputation and a 35-fold Ceritinib ic50 variation in process of care? Firstly, it should be asked whether the association is due to artefact or is a real association that does not appear to be explained by chance, bias or confounding. It is also crucial to consider whether

the measurement is an appropriate reflection of quality of care. Using amputations as an example (Atlas map 3) it is important to recognise that although amputations are a reasonable guide of foot care, early amputation can sometimes be a better outcome than delayed or absence of amputation2 which may even precipitate early death. Secondly, the interpretation of the data needs examining. AG-014699 molecular weight The data presented are adjusted for differences in the distribution of age and sex between different populations. However, other variables, such as deprivation, smoking status and ethnicity, which are known to be associated with risk of amputation and vary by region and could therefore confound the association, do not appear to have been considered in the comparisons of amputation rates. It may be that regions with lower amputation rates have diagnosed more patients with early onset in diabetes. In itself this is not a bad thing, but it will increase the denominator when calculating the rates of amputation. This LY294002 results in a lowering of rates

due to a statistical quirk rather than anything to do with improved foot care. It would thus be useful to know the adjusted prevalence of diagnosed diabetes in each region, or the rates of amputation per total population, as this would help in the interpretation of the data. Additionally, many patients in hospital with diabetes and co-existing conditions are not recorded as having diabetes.3 Rayman showed that only 74% of patients with diabetes undergoing amputation were recorded as having diabetes,4 and recent data from Scotland indicate that the proportion of people with diabetes who had diabetes recorded in routine hospital data varied from 34–88% between hospitals5 reflecting a large variation in a relatively small geographical area. In addition, many patients, who were diagnosed as having diabetes during the admission that led to an amputation, may not be recorded on discharge data as having diabetes.