Kif26a KO buy GW-572016 and HET mice are useful animal model of oligonephronia and secondary FSGS. Kif26a may be one of resposible genes for familial oligonephronia. SAIPRASERTKIT NALINEE1, KATAVETIN PISUT2, CHUENGSAMAN PIYATIDA3, SUANKRATAY CHUSANA4, KANJANABUCH TALERNGSAK2, EIAM-ONG SOMCHAI2, TUNGSANGA KRIANG2, THAILAND PERITONITIS STUDY GROUP* 1Division of Nephrology, Department of Medicine, Faculty of Medicine, Srinakharinwirot University, Bangkok, Thailand; 2Division of Nephrology, Department of Medicine, Faculty of Medicine, Chulalongkorn University,

Bangkok, Thailand; 3Banphaeo Hospital (Public Organization), Bangkok, Thailand; 4Division of Infectious Diseases, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand Introduction: Treatment of peritoneal dialysis (PD)-related gram-negative bacterial peritonitis with single antibiotic regimen according to anti-microbial susceptibility does not always yield a satisfactory outcome. Recently, the use of combined antibiotics in peritoneal dialysis-related peritonitis caused by gram-negative bacteria has been reported to have better outcome compared with single therapy in retrospective studies. However, there was no randomized small molecule library screening controlled study directly comparing these two regimens. Methods: A multicenter, randomized controlled study was conducted in 22 PD centers throughout the

nation over a 12-month period. After the anti-microbial susceptibility testing was determined, the community acquired PD-related gram-negative bacterial peritonitis patients were randomized to receive either single antibiotic or two synergistic antibiotics. The primary endpoint was a composite clinical outcome,

including failure of treatment, re-infection (relapsing, recurrent and repeat peritonitis), and patient death. Results: One hundred and three patients with gram-negative PD-related peritonitis were enrolled to this study. Fifty-two patients were randomized to single antibiotic group while 51 patients were randomized to double antibiotics group. Both groups had similar baseline IKBKE characteristics. The primary composite endpoint of single and double antibiotics group were similar (25.5 versus 25.0%, p = 0.96). There were also no difference in complete cure rate (88.5 versus 92.2%, p = 0.53), re-infection (relapsing, recurrent and repeat peritonitis) (17.9 versus 21.0%, p = 0.78) and death (12.9 versus 18.5%, p = 0.73) between both groups (single versus double). No antibiotic-associated adverse events were reported. Conclusions: Combined antibiotics did not provide additional benefits over single effective antibiotic in community-acquired PD-related gram-negative bacterial peritonitis. Therefore, treatment with two synergistic antibiotics should not be routinely prescribed in Thailand until there is more available supporting evidence. (ClinicalTrials.gov number, NCT01785641.