Results: COP location significantly correlated with a shift of the elements medially or laterally. The linear model describing this correlation was found to be statistically significant. Conclusion: There was significant correlation between the plantar orientation of the shoe device configuration and the COP.”
“Majewski osteodysplastic primordial dwarfism type II (MOP-DII) is caused by mutations in

the centrosome gene pericentrin (PCNT) that lead to severe pre- and postnatal growth retardation [1]. As in MOPDII patients, disruption of pericentrin (Pcnt) in mice caused a number of abnormalities find more including microcephaly, aberrant hemodynamics analyzed by in utero echocardiography, and cardiovascular anomalies; the latter being associated with mortality, as in the human condition [1]. To identify the mechanisms underlying these defects, we tested for changes in cell and molecular function. All Pcnt(-/-) mouse tissues and cells examined showed spindle misorientation. This mouse phenotype was associated with misdirected ventricular APR-246 septal growth in the heart, decreased proliferative symmetric divisions in brain neural

progenitors, and increased misoriented divisions in fibroblasts; the same phenotype was seen in fibroblasts from three MOPDII individuals. Misoriented spindles were associated with disrupted astral microtubules and near complete loss of a unique set of centrosome proteins from spindle poles (ninein, Cep215, centriolin). All these proteins appear to be crucial for microtubule anchoring and all interacted with Pcnt, suggesting that Pcnt serves as a molecular scaffold for this functionally linked set of spindle pole proteins. Importantly, Pcnt disruption had no detectable effect on localization of proteins involved in the cortical polarity pathway (NuMA, p150(glued), aPKC). Not only do these data reveal a spindle-pole-localized complex for spindle orientation, but they identify key spindle symmetry proteins involved in the pathogenesis of MOPDII.”
“Background: Acute mountain sickness (AMS) is common in high-altitude travellers, LY2090314 concentration and may lead to life-threatening high-altitude cerebral oedema. To better target pre-travel counselling, we aimed to characterize

the risk factors for AMS that may be identified prior to departure. Methods: We performed a descriptive study of high-altitude travellers who consulted at a travel clinic before departure. Data were collected by phone after their return, using a standardized questionnaire. Results: 162 adults were enrolled. Most subjects (81.5%) were informed about AMS before departure, by a medical doctor in 40% of cases. AMS symptoms were reported by 77 travellers (47.5%). Variables significantly associated with AMS symptoms were female sex (56% versus 38.5%, p = 0.01), trip organised by a travel agency (55.2% versus 43.3%, p = 0.03), travel duration (mean, 4.2 +/- 3.5 weeks in patients with AMS, versus 6.6 +/- 7.5 weeks in patients without AMS, p = 0.