The Norwegian Mother and Child Cohort Study is an observational, prospective cohort study conducted Daporinad by the Norwegian Institute of Public Health and has

been collecting data on pregnant women between 1999 and 2007.23 The main objective of The Norwegian Mother and Child Cohort Study is to evaluate the effect of an extensive number of exposures on pregnancy outcome, and the health status of the mother and child during and after pregnancy. The Medical Birth Registry of Norway24 has been prospectively collecting information on pregnancy, delivery, and the health of the neonate on all births in Norway since 1967. Data on all live births, still births after 16 weeks and elective abortions after week 12 are included in the registry. The information in The Norwegian Mother and Child Ensartinib clinical trial Cohort Study and data in the Medical Birth Registry of Norway were linked via the women’s personal identification number, which is assigned to every person legally residing in Norway and which is derived from the individual’s date of birth. The study was approved by the Regional Committee for Ethics in Medical Research, Region South, and

the Norwegian Data Inspectorate. Data Collection.— Information from The Norwegian Mother and Child Cohort Study was obtained from 2 self-administered questionnaires. Pregnant women living in Norway between 1999 and 2006 received a postal invitation prior to their first ultrasound scan between gestational weeks 17 and 18. The invitation new included an informed consent – form and the first questionnaire. The first questionnaire covered sociodemographic data, maternal medical history, drug exposure, and other exposures during the 6 months prior to pregnancy and during the first 18 weeks of the current pregnancy. The second questionnaire,

distributed during gestational week 30, covered lifestyle and medical data during the second and third trimesters. Information in the Medical Birth Registry of Norway24 was obtained from mandatory, standardized forms covering both sociodemographic and medical information regarding both the mother and the newborn. The forms are filled out by midwives, obstetricians, and/or pediatricians at each delivery, and information on the mother is obtained from the mother’s pregnancy medical records. Study Population.— The study population consisted of 69,929 pregnant women and their newborn children with records both in The Norwegian Mother and Child Cohort Study and in the Medical Birth Registry of Norway. Multiple pregnancies were not excluded in this study; however, only data on the first born infant were used as these were the only ones also linked to maternal data. Explanatory Variables.