2 Candida buy MAPK Inhibitor Library spp. are more frequently isolated from the fitting surface of dentures when compared to the corresponding region of the oral mucosa. 1 Therefore, the treatment of denture-induced stomatitis should include denture cleansing and disinfection in addition to topic or systemic antifungal drugs. Although these treatments do show some efficacy, they aim at inactivating the microorganisms after denture surface colonization. As the adhesion of microorganisms to denture surfaces is a prerequisite for microbial colonization, 3 and 4 the development of methods that can reduce C. albicans adhesion may represent a significant advance in the prevention of denture-induce stomatitis. The use

of polymers containing zwitterionic groups such as phosphatidylcholines and sulfobetaines,5, 6, 7, 8, 9 and 10 which originate from the simulation of biomembranes,9 and 11 has

been proposed to modify the surface of biomaterials.12, 13 and 14 A significant reduction in protein adsorption has been demonstrated5, 8, 9, 10, 12, 13, 14, 15, 16, 17 and 18 and attributed to the formation of a hydration layer on the material surface5, 6, 7, 9, 10, 11, 12, 13, 14, 16, 17 and 19 that prevents the conformational alteration of these proteins.9, 11, 13, 14 and 19 Previous researchers7, 13, 16, 20 and 21 reported that sulfobetaine application on substrate surfaces reduced bacterial adhesion. These results suggest that sulfobetaine-based polymers may be used to modify the surface of acrylic materials used 3-oxoacyl-(acyl-carrier-protein) reductase this website in the fabrication of removable dentures and reduce microbial adhesion.6 However, the effectiveness of this surface modification on C. albicans adhesion remains to be investigated. Surface modification by deposition of polymer coatings such as parylene has been reported to improve the wettability of a silicone

elastomer and reduce C. albicans adhesion and aggregation on its surface. 22 Hydrophilic polymers have also been investigated in biomaterial research. 19, 23 and 24 The hydration state of hydrophilic polymers is different from that of zwitterionic polymers, and the free water fraction on polymer surface is lower in the former. 19 Despite these differences, hydrophilic polymers have been used to modify the surface of biomaterials and reduce bacterial adhesion. 23 and 24 The adsorption of proteins to neutral hydrophilic surfaces is relatively weak, while their adsorption to hydrophobic surfaces tends to be very strong and practically irreversible. 25 and 26 Therefore, altering the characteristics of the inner surfaces of dentures by increasing their hydrophilicity could reduce colonization by pathogenic microorganisms, including Candida spp. It has been reported that substratum surface properties, such as surface free energy, may influence C. albicans adhesion to polymers, where hydrophobic interactions play a role.